XRCC2 mutation causes meiotic arrest, azoospermia and infertility

BACKGROUND: Meiotic homologous recombination (HR) plays an essential role in gametogenesis. In most eukaryotes, meiotic HR is mediated by two recombinase systems: ubiquitous RAD51 and meiosis-specific DMC1. In the RAD51-mediated HR system, RAD51 and five RAD51 paralogues are essential for normal RAD...

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Detalhes bibliográficos
Publicado no:J Med Genet
Main Authors: Yang, Yongjia, Guo, Jihong, Dai, Lei, Zhu, Yimin, Hu, Hao, Tan, Lihong, Chen, Weijian, Liang, Desheng, He, Jingliang, Tu, Ming, Wang, Kewei, Wu, Lingqian
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2018
Assuntos:
Novel Disease Loci
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6119352/
https://ncbi.nlm.nih.gov/pubmed/30042186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jmedgenet-2017-105145
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