Hematopoietic stem cell loss and hematopoietic failure in severe aplastic anemia is driven by macrophages and aberrant podoplanin expression

Severe aplastic anemia (SAA) results from profound hematopoietic stem cell loss. T cells and interferon gamma (IFNγ) have long been associated with SAA, yet the underlying mechanisms driving hematopoietic stem cell loss remain unknown. Using a mouse model of SAA, we demonstrate that IFNγ-dependent h...

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Bibliografiset tiedot
Julkaisussa:Haematologica
Päätekijät: McCabe, Amanda, Smith, Julianne N.P., Costello, Angelica, Maloney, Jackson, Katikaneni, Divya, MacNamara, Katherine C.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Ferrata Storti Foundation 2018
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6119154/
https://ncbi.nlm.nih.gov/pubmed/29773597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2018.189449
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