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The endothelial cell receptor stabilin-2 regulates VWF-FVIII complex half-life and immunogenicity

Quantitative abnormalities of the von Willebrand factor–factor VIII (VWF-FVIII) complex associate with inherited bleeding or thrombotic disorders. Receptor-mediated interactions between plasma VWF-FVIII and phagocytic or immune cells can influence their hemostatic and immunogenic activities. Genetic...

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Detalles Bibliográficos
Publicado en:J Clin Invest
Main Authors: Swystun, Laura L., Lai, Jesse D., Notley, Colleen, Georgescu, Ilinca, Paine, A. Simonne, Mewburn, Jeff, Nesbitt, Kate, Schledzewski, Kai, Géraud, Cyrill, Kzhyshkowska, Julia, Goerdt, Sergij, Hopman, Wilma, Montgomery, Robert R., James, Paula D., Lillicrap, David
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6118640/
https://ncbi.nlm.nih.gov/pubmed/30124466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI96400
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