Intestinal P-glycoprotein exports endocannabinoids to prevent inflammation and maintain homeostasis

Neutrophil influx into the intestinal lumen is a critical response to infectious agents, but is also associated with severe intestinal damage observed in idiopathic inflammatory bowel disease. The chemoattractant hepoxilin A(3), an eicosanoid secreted from intestinal epithelial cells by the apically...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Szabady, Rose L., Louissaint, Christopher, Lubben, Anneke, Xie, Bailu, Reeksting, Shaun, Tuohy, Christine, Demma, Zachary, Foley, Sage E., Faherty, Christina S., Llanos-Chea, Alejandro, Olive, Andrew J., Mrsny, Randall J., McCormick, Beth A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2018
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6118593/
https://ncbi.nlm.nih.gov/pubmed/30102254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI96817
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