Modulation of EZH2 expression in T cells improves efficacy of anti–CTLA-4 therapy

Enhancer of zeste homolog 2–mediated (EZH2-mediated) epigenetic regulation of T cell differentiation and Treg function has been described previously; however, the role of EZH2 in T cell–mediated antitumor immunity, especially in the context of immune checkpoint therapy, is not understood. Here, we s...

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Dades bibliogràfiques
Publicat a:J Clin Invest
Autors principals: Goswami, Sangeeta, Apostolou, Irina, Zhang, Jan, Skepner, Jill, Anandhan, Swetha, Zhang, Xuejun, Xiong, Liangwen, Trojer, Patrick, Aparicio, Ana, Subudhi, Sumit K., Allison, James P., Zhao, Hao, Sharma, Padmanee
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2018
Matèries:
Concise Communication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6118570/
https://ncbi.nlm.nih.gov/pubmed/29905573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI99760
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