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Interferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and function
Plasmacytoid dendritic cells (pDC) are essential for immune competence. Here we show that pDC precursor differentiated from human CD34(+) hematopoietic stem and progenitor cells (HSPC) has low surface expression of pDC markers, and has limited induction of type I interferon (IFN) and IL-6 upon TLR7...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6117296/ https://ncbi.nlm.nih.gov/pubmed/30166549 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05816-y |
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