Interferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and function

Plasmacytoid dendritic cells (pDC) are essential for immune competence. Here we show that pDC precursor differentiated from human CD34(+) hematopoietic stem and progenitor cells (HSPC) has low surface expression of pDC markers, and has limited induction of type I interferon (IFN) and IL-6 upon TLR7...

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Bibliografiska uppgifter
I publikationen:Nat Commun
Huvudupphovsmän: Laustsen, A., Bak, R. O., Krapp, C., Kjær, L., Egedahl, J. H., Petersen, C. C., Pillai, S., Tang, H. Q., Uldbjerg, N., Porteus, M., Roan, N. R., Nyegaard, M., Denton, P. W., Jakobsen, M. R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2018
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6117296/
https://ncbi.nlm.nih.gov/pubmed/30166549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05816-y
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