Red Blood Cells in Type 2 Diabetes Impair Cardiac Post-Ischemic Recovery Through an Arginase-Dependent Modulation of Nitric Oxide Synthase and Reactive Oxygen Species

This study tested the hypothesis that red blood cell (RBC) arginase represents a potential therapeutic target in ischemia-reperfusion in type 2 diabetes. Post-ischemic cardiac recovery was impaired in hearts from db/db mice compared with wild-type hearts. RBCs from mice and patients with type 2 diab...

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Detalhes bibliográficos
Publicado no:JACC Basic Transl Sci
Main Authors: Yang, Jiangning, Zheng, Xiaowei, Mahdi, Ali, Zhou, Zhichao, Tratsiakovich, Yahor, Jiao, Tong, Kiss, Attila, Kövamees, Oskar, Alvarsson, Michael, Catrina, Sergiu-Bogdan, Lundberg, Jon O., Brismar, Kerstin, Pernow, John
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
Assuntos:
PRECLINICAL RESEARCH
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6115643/
https://ncbi.nlm.nih.gov/pubmed/30175269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacbts.2018.03.006
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