Analyzing 2,000 in vivo Drug Delivery Data Points Reveals Cholesterol Structure Impacts Nanoparticle Delivery

Lipid nanoparticles (LNPs) are formulated using unmodified cholesterol. However, cholesterol is naturally esterified and oxidized in vivo, and these cholesterol variants are differentially trafficked in vivo via lipoproteins including LDL and VLDL. We hypothesized that incorporating the same cholest...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:ACS Nano
Egile Nagusiak: Paunovska, Kalina, Gil, Carmen J., Lokugamage, Melissa P., Sago, Cory D., Sato, Manaka, Lando, Gwyn N., Castro, Marielena Gamboa, Bryksin, Anton V., Dahlman, James E.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2018
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6115295/
https://ncbi.nlm.nih.gov/pubmed/30016076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsnano.8b03640
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