Analyzing 2,000 in vivo Drug Delivery Data Points Reveals Cholesterol Structure Impacts Nanoparticle Delivery

Lipid nanoparticles (LNPs) are formulated using unmodified cholesterol. However, cholesterol is naturally esterified and oxidized in vivo, and these cholesterol variants are differentially trafficked in vivo via lipoproteins including LDL and VLDL. We hypothesized that incorporating the same cholest...

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Detaylı Bibliyografya
Yayımlandı:ACS Nano
Asıl Yazarlar: Paunovska, Kalina, Gil, Carmen J., Lokugamage, Melissa P., Sago, Cory D., Sato, Manaka, Lando, Gwyn N., Castro, Marielena Gamboa, Bryksin, Anton V., Dahlman, James E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6115295/
https://ncbi.nlm.nih.gov/pubmed/30016076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsnano.8b03640
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