Suppression of SOCS3 enhances TRAIL-induced cell growth inhibition through the upregulation of DR4 expression in renal cell carcinoma cells

BACKGROUND: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a tumor-selective apoptosis inducer that is expressed in natural killer cells, whose cytotoxicity is activated by interferon (IFN). We investigated the effect of suppressor of cytokine signaling (SOCS) 3 on the expression...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Yabe, Michihiro, Ishibashi, Kei, Onagi, Akifumi, Tanji, Ryo, Honda-Takinami, Ruriko, Koguchi, Tomoyuki, Matsuoka, Kanako, Hoshi, Seiji, Hata, Junya, Kataoka, Masao, Ogawa, Soichiro, Hiraki, Hiroyuki, Haga, Nobuhiro, Kojima, Yoshiyuki
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6114968/
https://ncbi.nlm.nih.gov/pubmed/30167088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25851
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