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Harnessing the biological complexity of Big Data from LINCS gene expression signatures

Gene expression profiling using transcriptional drug perturbations are useful for many biomedical discovery studies including drug repurposing and elucidation of drug mechanisms (MoA) and many other pharmacogenomic applications. However, limited data availability across cell types has severely hinde...

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Bibliographische Detailangaben
Veröffentlicht in:PLoS One
Hauptverfasser: Musa, Aliyu, Tripathi, Shailesh, Kandhavelu, Meenakshisundaram, Dehmer, Matthias, Emmert-Streib, Frank
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6114505/
https://ncbi.nlm.nih.gov/pubmed/30157183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0201937
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