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Syntheses of Highly Functionalized Spirocyclohexenes by Formal [4+2] Annulation of Arylidene Azlactones with Allenoates

A straightforward phosphine‐catalyzed formal [4+2] annulation between α‐branched allenoates and arylidene azlactones has been developed to access highly functionalized spirocyclohexenes. This cyclization favors the γ‐addition of the phosphine‐activated allenoates over a β′‐addition pathway. Detailed...

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Detalhes bibliográficos
Publicado no:Asian J Org Chem
Main Authors: Eitzinger, Andreas, Zielke, Katharina, Widhalm, Michael, Robiette, Raphaël, Waser, Mario
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6114148/
https://ncbi.nlm.nih.gov/pubmed/30175031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ajoc.201800275
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