The Role of the L-Type Ca(2+) Channel in Altered Metabolic Activity in a Murine Model of Hypertrophic Cardiomyopathy

Heterozygous mice (αMHC(403/+)) expressing the human disease-causing mutation Arg403Gln exhibit cardinal features of hypertrophic cardiomyopathy (HCM) including hypertrophy, myocyte disarray, and increased myocardial fibrosis. Treatment of αMHC(403/+)mice with the L-type calcium channel (I(Ca-L)) an...

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Bibliographic Details
Published in:JACC Basic Transl Sci
Main Authors: Viola, Helena M., Johnstone, Victoria P.A., Cserne Szappanos, Henrietta, Richman, Tara R., Tsoutsman, Tatiana, Filipovska, Aleksandra, Semsarian, Christopher, Seidman, Jonathan G., Seidman, Christine E., Hool, Livia C.
Format: Artigo
Language:Inglês
Published: Elsevier 2016
Subjects:
PRE-CLINICAL RESEARCH
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6113168/
https://ncbi.nlm.nih.gov/pubmed/30167506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacbts.2015.12.001
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