Activation of CD1d-restricted T cells protects NOD mice from developing diabetes by regulating dendritic cell subsets

CD1d-restricted invariant NKT (iNKT) cells are immunoregulatory cells whose loss exacerbates diabetes in nonobese diabetic (NOD) female mice. Here, we show that the relative numbers of iNKT cells from the pancreatic islets of NOD mice decrease at the time of conversion from peri-insulitis to invasiv...

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Bibliographische Detailangaben
Hauptverfasser: Naumov, Yuri N., Bahjat, Keith S., Gausling, Rudolph, Abraham, Roshini, Exley, Mark A., Koezuka, Yasuhiko, Balk, Steven B., Strominger, Jack L., Clare-Salzer, Michael, Wilson, S. Brian
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences 2001
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC61128/
https://ncbi.nlm.nih.gov/pubmed/11707602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.251531798
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