WDR5 modulates cell motility and morphology and controls nuclear changes induced by a 3D environment

Cell migration through extracellular matrices requires nuclear deformation, which depends on nuclear stiffness. In turn, chromatin structure contributes to nuclear stiffness, but the mechanosensing pathways regulating chromatin during cell migration remain unclear. Here, we demonstrate that WD repea...

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Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Wang, Pengbo, Dreger, Marcel, Madrazo, Elena, Williams, Craig J., Samaniego, Rafael, Hodson, Nigel W., Monroy, Francisco, Baena, Esther, Sánchez-Mateos, Paloma, Hurlstone, Adam, Redondo-Muñoz, Javier
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2018
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6112728/
https://ncbi.nlm.nih.gov/pubmed/29987046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1719405115
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