DUSP6 mediates T cell receptor-engaged glycolysis and restrains T(FH) cell differentiation

Activated T cells undergo metabolic reprogramming and effector-cell differentiation but the factors involved are unclear. Utilizing mice lacking DUSP6 (DUSP6(−/−)), we show that this phosphatase regulates T cell receptor (TCR) signaling to influence follicular helper T (T(FH)) cell differentiation a...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Hsu, Wei-Chan, Chen, Ming-Yu, Hsu, Shu-Ching, Huang, Li-Rung, Kao, Cheng-Yuan, Cheng, Wen-Hui, Pan, Chien-Hsiung, Wu, Ming-Sian, Yu, Guann-Yi, Hung, Ming-Shiu, Leu, Chuen-Miin, Tan, Tse-Hua, Su, Yu-Wen
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2018
Pynciau:
PNAS Plus
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6112722/
https://ncbi.nlm.nih.gov/pubmed/30087184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1800076115
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