Mucosal antibody responses to vaccines targeting SIV protease cleavage sites or full-length Gag and Env proteins in Mauritian cynomolgus macaques

HIV mutates rapidly and infects CD4(+) T cells, especially when they are activated. A vaccine targeting conserved, essential viral elements while limiting CD4(+) T cell activation could be effective. Learning from natural immunity observed in a group of highly HIV-1 exposed seronegative Kenyan femal...

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Dettagli Bibliografici
Pubblicato in:PLoS One
Autori principali: Li, Hongzhao, Hai, Yan, Lim, So-Yon, Toledo, Nikki, Crecente-Campo, Jose, Schalk, Dane, Li, Lin, Omange, Robert W., Dacoba, Tamara G., Liu, Lewis R., Kashem, Mohammad Abul, Wan, Yanmin, Liang, Binhua, Li, Qingsheng, Rakasz, Eva, Schultz-Darken, Nancy, Alonso, Maria J., Plummer, Francis A., Whitney, James B., Luo, Ma
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2018
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6112674/
https://ncbi.nlm.nih.gov/pubmed/30153293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0202997
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