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Impairment of MAD2B–PRCC interaction in mitotic checkpoint defective t(X;1)-positive renal cell carcinomas

The papillary renal cell carcinoma (RCC)-associated (X;1)(p11;q21) translocation fuses the genes PRCC and TFE3 and leads to cancer by an unknown molecular mechanism. We here demonstrate that the mitotic checkpoint protein MAD2B interacts with PRCC. The PRCCTFE3 fusion protein retains the MAD2B inter...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Weterman, Marian A. J., van Groningen, Jan J. M., Tertoolen, Leon, van Kessel, Ad Geurts
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences 2001
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC61123/
https://ncbi.nlm.nih.gov/pubmed/11717438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.241304198
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