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Highly GSH-sensitive SN-38 prodrug with “OFF-to-ON” fluorescence switch as a bifunctional anticancer agent
SN-38 (7-ethyl-10-hydroxy-camptothecin) is an active metabolite of irinotecan (CPT-11) and the most potent camptothecin analogue. In this study, 2,4-dinitrobenzene sulfonyl (DNS) was covalently conjugated as GSH-sensitive trigger to 10’ –OH of SN-38 to yield a GSH-sensitive prodrug, denoted as DNS-S...
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| Publicado no: | Chem Commun (Camb) |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6112243/ https://ncbi.nlm.nih.gov/pubmed/30047958 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8cc05010d |
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