Dual BRD4 and AURKA Inhibition Is Synergistic against MYCN-Amplified and Nonamplified Neuroblastoma()

A majority of cases of high-risk neuroblastoma, an embryonal childhood cancer, are driven by MYC or MYCN-driven oncogenic signaling. While considered to be directly “undruggable” therapeutically, MYC and MYCN can be repressed transcriptionally by inhibition of Bromodomain-containing protein 4 (BRD4)...

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Udgivet i:Neoplasia
Main Authors: Felgenhauer, Joshua, Tomino, Laura, Selich-Anderson, Julia, Bopp, Emily, Shah, Nilay
Format: Artigo
Sprog:Inglês
Udgivet: Neoplasia Press 2018
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Original article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6111011/
https://ncbi.nlm.nih.gov/pubmed/30153557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2018.08.002
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