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Role of solvent accessibility for aggregation-prone patches in protein folding
The arrangement of amino acids in a protein sequence encodes its native folding. However, the same arrangement in aggregation-prone regions may cause misfolding as a result of local environmental stress. Under normal physiological conditions, such regions congregate in the protein’s interior to avoi...
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| Publicado en: | Sci Rep |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6110721/ https://ncbi.nlm.nih.gov/pubmed/30150761 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-31289-6 |
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