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Role of solvent accessibility for aggregation-prone patches in protein folding

The arrangement of amino acids in a protein sequence encodes its native folding. However, the same arrangement in aggregation-prone regions may cause misfolding as a result of local environmental stress. Under normal physiological conditions, such regions congregate in the protein’s interior to avoi...

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Foilsithe in:Sci Rep
Main Authors: Mishra, Avinash, Ranganathan, Shoba, Jayaram, B., Sattar, Abdul
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2018
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6110721/
https://ncbi.nlm.nih.gov/pubmed/30150761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-31289-6
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