The roles of SMYD4 in epigenetic regulation of cardiac development in zebrafish

SMYD4 belongs to a family of lysine methyltransferases. We analyzed the role of smyd4 in zebrafish development by generating a smyd4 mutant zebrafish line (smyd4(L544Efs*1)) using the CRISPR/Cas9 technology. The maternal and zygotic smyd4(L544Efs*1) mutants demonstrated severe cardiac malformations,...

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Udgivet i:PLoS Genet
Main Authors: Xiao, Deyong, Wang, Huijun, Hao, Lili, Guo, Xiao, Ma, Xiaojing, Qian, Yanyan, Chen, Hongbo, Ma, Jing, Zhang, Jin, Sheng, Wei, Shou, Weinian, Huang, Guoying, Ma, Duan
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6110521/
https://ncbi.nlm.nih.gov/pubmed/30110327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007578
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