CD28 deficiency leads to accumulation of germinal-center independent IgM(+) experienced B cells and to production of protective IgM during experimental malaria

Protective immunity to blood-stage malaria is attributed to Plasmodium-specific IgG and effector-memory T helper 1 (Th1) cells. However, mice lacking the costimulatory receptor CD28 (CD28KO) maintain chronic parasitemia at low levels and do not succumb to infection, suggesting that other immune resp...

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Bibliografski detalji
Izdano u:PLoS One
Glavni autori: Borges da Silva, Henrique, Machado de Salles, Érika, Lima-Mauro, Eliana Faquim, Sardinha, Luiz Roberto, Álvarez, José Maria, D’Império Lima, Maria Regina
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2018
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6110469/
https://ncbi.nlm.nih.gov/pubmed/30148845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0202522
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