Investigating the effects of nintedanib on biomarkers of extracellular matrix turnover in patients with IPF: design of the randomised placebo-controlled INMARK®trial

INTRODUCTION: A feature of the pathogenesis of idiopathic pulmonary fibrosis (IPF) is the excess accumulation of extracellular matrix (ECM) in the lungs. Cleavage of the ECM by metalloproteinases (MMPs) generates free-circulating protein fragments known as neoepitopes. The PROFILE study suggested th...

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Detalhes bibliográficos
Publicado no:BMJ Open Respir Res
Main Authors: Maher, Toby M, Stowasser, Susanne, Nishioka, Yasuhiko, White, Eric S, Cottin, Vincent, Noth, Imre, Selman, Moisés, Blahova, Zuzana, Wachtlin, Daniel, Diefenbach, Claudia, Jenkins, R Gisli
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2018
Assuntos:
Interstitial Lung Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6109823/
https://ncbi.nlm.nih.gov/pubmed/30167310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/bmjresp-2018-000325
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