Obstructive Lymphangitis Precedes Colitis in Murine Norovirus–Infected Stat1-Deficient Mice

Murine norovirus (MNV) is an RNA virus that can prove lethal in mice with impaired innate immunity. We found that MNV-4 infection of Stat1(−/−) mice was not lethal, but produced a 100% penetrant, previously undescribed lymphatic phenotype characterized by chronic-active lymphangitis with hepatitis,...

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Udgivet i:Am J Pathol
Main Authors: Seamons, Audrey, Treuting, Piper M., Meeker, Stacey, Hsu, Charlie, Paik, Jisun, Brabb, Thea, Escobar, Sabine S., Alexander, Jonathan S., Ericsson, Aaron C., Smith, Jason G., Maggio-Price, Lillian
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6109697/
https://ncbi.nlm.nih.gov/pubmed/29753791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2018.03.019
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