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Loss of Gαq impairs regulatory B-cell function

BACKGROUND: Recent studies have shown a crucial role of Gαq in immune regulation, but how Gαq modulates regulatory B-cell (Breg) function is still unclear. We address this here. METHODS: CD19(+)IL-10(+) Bregs of wild-type (WT) and Gnaq(−/−) mice were analyzed by flow cytometry after stimulation by l...

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Detalhes bibliográficos
Publicado no:Arthritis Res Ther
Main Authors: He, Yan, Yuan, Xiaoqing, Li, Yan, Zhong, Chunlian, Liu, Yuan, Qian, Hongyan, Xuan, Jingxiu, Duan, Lihua, Shi, Guixiu
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6109260/
https://ncbi.nlm.nih.gov/pubmed/30143054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-018-1682-0
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