Neurofilament light chain and tau concentrations are markedly increased in the serum of patients with sporadic Creutzfeldt-Jakob disease, and tau correlates with rate of disease progression

OBJECTIVES: A blood-based biomarker of neuronal damage in sporadic Creutzfeldt-Jakob disease (sCJD) will be extremely valuable for both clinical practice and research aiming to develop effective therapies. METHODS: We used an ultrasensitive immunoassay to measure two candidate biomarkers, tau and ne...

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Udgivet i:J Neurol Neurosurg Psychiatry
Main Authors: Thompson, Andrew Geoffrey Bourne, Luk, Connie, Heslegrave, Amanda J, Zetterberg, Henrik, Mead, Simon H, Collinge, John, Jackson, Graham S
Format: Artigo
Sprog:Inglês
Udgivet: BMJ Publishing Group 2018
Fag:
Neurodegeneration
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6109239/
https://ncbi.nlm.nih.gov/pubmed/29487167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jnnp-2017-317793
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