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The cristae modulator Optic atrophy 1 requires mitochondrial ATP synthase oligomers to safeguard mitochondrial function
It is unclear how the mitochondrial fusion protein Optic atrophy 1 (OPA1), which inhibits cristae remodeling, protects from mitochondrial dysfunction. Here we identify the mitochondrial F(1)F(o)-ATP synthase as the effector of OPA1 in mitochondrial protection. In OPA1 overexpressing cells, the loss...
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Publicado no: | Nat Commun |
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Main Authors: | , , , , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Nature Publishing Group UK
2018
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6109181/ https://ncbi.nlm.nih.gov/pubmed/30143614 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05655-x |
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