p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1

p53 is a well-known tumor suppressor that has emerged as an important player in energy balance. However, its metabolic role in the hypothalamus remains unknown. Herein, we show that mice lacking p53 in agouti-related peptide (AgRP), but not proopiomelanocortin (POMC) or steroidogenic factor-1 (SF1)...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Quiñones, Mar, Al-Massadi, Omar, Folgueira, Cintia, Bremser, Stephan, Gallego, Rosalía, Torres-Leal, Leonardo, Haddad-Tóvolli, Roberta, García-Caceres, Cristina, Hernandez-Bautista, Rene, Lam, Brian Y. H., Beiroa, Daniel, Sanchez-Rebordelo, Estrella, Senra, Ana, Malagon, Jose A., Valerio, Patricia, Fondevila, Marcos F., Fernø, Johan, Malagon, Maria M., Contreras, Raian, Pfluger, Paul, Brüning, Jens C., Yeo, Giles, Tschöp, Matthias, Diéguez, Carlos, López, Miguel, Claret, Marc, Kloppenburg, Peter, Sabio, Guadalupe, Nogueiras, Ruben
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6109113/
https://ncbi.nlm.nih.gov/pubmed/30143607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05711-6
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