Discovery and optimization of a new class of pyruvate kinase inhibitors as potential therapeutics for the treatment of methicillin-resistant Staphylococcus aureus infections

A novel series of bis-indoles derived from naturally occurring marine alkaloid 4 were synthesized and evaluated as inhibitors of methicillin-resistant Staphylococcus aureus (MRSA) pyruvate kinase (PK). PK is not only critical for bacterial survival which would make it a target for development of nov...

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Pubblicato in:Bioorg Med Chem
Autori principali: Kumar, Nag S., Dullaghan, Edie M., Brett Finlay, B., Gong, Huansheng, Reiner, Neil E., Jon Paul Selvam, J., Thorson, Lisa M., Campbell, Sara, Vitko, Nicholas, Richardson, Anthony R., Zoraghi, Roya, Young, Robert N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6108325/
https://ncbi.nlm.nih.gov/pubmed/24508307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2014.01.020
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