Structure and mechanism of cancer-associated N-acetylglucosaminyltransferase-V

N-acetylglucosaminyltransferase-V (GnT-V) alters the structure of specific N-glycans by modifying α1-6-linked mannose with a β1-6-linked N-acetylglucosamine branch. β1-6 branch formation on cell surface receptors accelerates cancer metastasis, making GnT-V a promising target for drug development. Ho...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Nagae, Masamichi, Kizuka, Yasuhiko, Mihara, Emiko, Kitago, Yu, Hanashima, Shinya, Ito, Yukishige, Takagi, Junichi, Taniguchi, Naoyuki, Yamaguchi, Yoshiki
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6107550/
https://ncbi.nlm.nih.gov/pubmed/30140003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05931-w
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