Epithelial-to-mesenchymal transition (EMT) causing acquired resistance to afatinib in a patient with epidermal growth factor receptor (EGFR)-mutant lung adenocarcinoma

We report the first case of epithelial-to-mesenchymal transition (EMT) as the cause of acquired resistance to the second-generation EGFR-tyrosine kinase inhibitor (TKI), afatinib in a patient with advanced non-small cell lung cancer (NSCLC) harboring a sensitizing EGFR mutation. Patients with EGFR-m...

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Detalhes bibliográficos
Publicado no:J Thorac Dis
Main Authors: Poh, Mau-Ern, Liam, Chong-Kin, Rajadurai, Pathmanathan, Chai, Chee-Shee
Formato: Artigo
Idioma:Inglês
Publicado em: AME Publishing Company 2018
Assuntos:
Case Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6105946/
https://ncbi.nlm.nih.gov/pubmed/30174934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21037/jtd.2018.06.122
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