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Iron Restriction to Clinical Isolates of Candida albicans by the Novel Chelator DIBI Inhibits Growth and Increases Sensitivity to Azoles In Vitro and In Vivo in a Murine Model of Experimental Vaginitis

Candida albicans is an important opportunistic pathogen causing various human infections that are often treated with azole antifungals. The U.S. CDC now regards developing candidal antifungal resistance as a threat, creating a need for new and more effective antifungal treatments. Iron is an essenti...

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Bibliografske podrobnosti
izdano v:Antimicrob Agents Chemother
Main Authors: Savage, Kimberley A., Parquet, Maria del Carmen, Allan, David S., Davidson, Ross J., Holbein, Bruce E., Lilly, Elizabeth A., Fidel, Paul L.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6105849/
https://ncbi.nlm.nih.gov/pubmed/29844048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02576-17
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