ClpA and HtpX Proteases Are Involved in Intrinsic Aminoglycoside Resistance of Stenotrophomonas maltophilia and Are Potential Aminoglycoside Adjuvant Targets

The linkage of the protease-chaperon system, SmeYZ pump, and aminoglycoside resistance was assessed in Stenotrophomonas maltophilia. The clpA, clpS, clpP, and htpX genes were upregulated in response to kanamycin exposure. Of these, clpA and htpX were the primary determinants responsible for intrinsi...

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Dettagli Bibliografici
Pubblicato in:Antimicrob Agents Chemother
Autori principali: Huang, Hsin-Hui, Lin, Yi-Tsung, Chen, Peng-Ying, Li, Li-Hua, Ning, Hsiao-Chen, Yang, Tsuey-Ching
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2018
Soggetti:
Mechanisms of Resistance
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6105848/
https://ncbi.nlm.nih.gov/pubmed/29760139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00554-18
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