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Nephrotoxicity Associated with Intravenous Polymyxin B Once- versus Twice-Daily Dosing Regimen

Nephrotoxicity is a known adverse effect of polymyxin B (PMB). Animal data suggest that once-daily dosing may reduce the rate and delay the onset of acute kidney injury (AKI). In a multicenter retrospective study, we evaluated adult patients with a creatinine clearance (CrCl) of ≥30 ml/min who recei...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Antimicrob Agents Chemother
Prif Awduron: Okoduwa, Adeola, Ahmed, Nabeela, Guo, Yi, Scipione, Marco R., Papadopoulos, John, Eiras, Daniel P., Dubrovskaya, Yanina
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2018
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6105789/
https://ncbi.nlm.nih.gov/pubmed/29844039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00025-18
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