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Elevated free hemoglobin and decreased haptoglobin levels are associated with adverse clinical outcomes, unfavorable physiologic measures and altered inflammatory markers in pediatric cardiac surgery patients

BACKGROUND: There are clinical, mechanistic and animal model data suggesting that free hemoglobin, heme and iron may contribute to infection, thrombosis, multi-organ failure and death in critically ill patients. These outcomes may be mitigated by hemoglobin binding proteins such as haptoglobin. METH...

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Dettagli Bibliografici
Pubblicato in:Transfusion
Autori principali: Cholette, Jill M, Pietropaoli, Anthony P, Henrichs, Kelly F, Alfieris, George M, Powers, Karen S, Gensini, Francisco, Rubenstein, Jeffrey S., Sweeney, Dawn, Phipps, Richard, Spinelli, Sherry L., Refaai, Majed A., Eaton, Michael P., Blumberg, Neil
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6105435/
https://ncbi.nlm.nih.gov/pubmed/29603246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/trf.14601
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