Elevated free hemoglobin and decreased haptoglobin levels are associated with adverse clinical outcomes, unfavorable physiologic measures and altered inflammatory markers in pediatric cardiac surgery patients

BACKGROUND: There are clinical, mechanistic and animal model data suggesting that free hemoglobin, heme and iron may contribute to infection, thrombosis, multi-organ failure and death in critically ill patients. These outcomes may be mitigated by hemoglobin binding proteins such as haptoglobin. METH...

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Detalhes bibliográficos
Publicado no:Transfusion
Main Authors: Cholette, Jill M, Pietropaoli, Anthony P, Henrichs, Kelly F, Alfieris, George M, Powers, Karen S, Gensini, Francisco, Rubenstein, Jeffrey S., Sweeney, Dawn, Phipps, Richard, Spinelli, Sherry L., Refaai, Majed A., Eaton, Michael P., Blumberg, Neil
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6105435/
https://ncbi.nlm.nih.gov/pubmed/29603246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/trf.14601
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