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Valproic acid is protective in cellular and worm models of oculopharyngeal muscular dystrophy

OBJECTIVE: To explore valproic acid (VPA) as a potentially beneficial drug in cellular and worm models of oculopharyngeal muscular dystrophy (OPMD). METHODS: Using a combination of live cell imaging and biochemical measures, we evaluated the potential protective effect of VPA in a stable C2C12 muscl...

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Detalhes bibliográficos
Publicado no:Neurology
Main Authors: Abu-Baker, Aida, Parker, Alex, Ramalingam, Siriram, Laganiere, Janet, Brais, Bernard, Neri, Christian, Dion, Patrick, Rouleau, Guy
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6105050/
https://ncbi.nlm.nih.gov/pubmed/30006409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0000000000005942
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