Complement inhibition ameliorates blast-induced acute lung injury in rats: Potential role of complement in intracellular HMGB1-mediated inflammation

BACKGROUND AND OBJECTIVE: Complement activation as an early and important inflammatory process contributes to multiple organ dysfunction after trauma. We have recently shown that complement inhibition by decay-accelerating factor (DAF) protects brain from blast-overpressure (BOP)-induced damage. Thi...

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Bibliographic Details
Published in:PLoS One
Main Authors: Li, Yansong, Yang, Zhangsheng, Chavko, Mikulas, Liu, Bin, Aderemi, Olawale A., Simovic, Milomir O., Dubick, Michael A., Cancio, Leopoldo C.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2018
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6105023/
https://ncbi.nlm.nih.gov/pubmed/30133517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0202594
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