Noninvasive assessment of dofetilide plasma concentration using a deep learning (neural network) analysis of the surface electrocardiogram: A proof of concept study

BACKGROUND: Dofetilide is an effective antiarrhythmic medication for rhythm control in atrial fibrillation, but carries a significant risk of pro-arrhythmia and requires meticulous dosing and monitoring. The cornerstone of this monitoring, measurement of the QT/QTc interval, is an imperfect surrogat...

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Publicado en:PLoS One
Main Authors: Attia, Zachi I., Sugrue, Alan, Asirvatham, Samuel J., Ackerman, Michael J., Kapa, Suraj, Friedman, Paul A., Noseworthy, Peter A.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2018
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6104915/
https://ncbi.nlm.nih.gov/pubmed/30133452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0201059
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