Mexiletine rescues a mixed biophysical phenotype of the cardiac sodium channel arising from the SCN5A mutation, N406K, found in LQT3 patients

Introduction: Individual mutations in the SCN5A-encoding cardiac sodium channel α-subunit usually cause a single cardiac arrhythmia disorder, some cause mixed biophysical or clinical phenotypes. Here we report an infant, female patient harboring a N406K mutation in SCN5A with a marked and mixed biop...

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Detalhes bibliográficos
Publicado no:Channels (Austin)
Main Authors: Hu, Rou-Mu, Tester, David J., Li, Ryan, Sun, Tianyu, Peterson, Blaise Z., Ackerman, Michael J., Makielski, Jonathan C., Tan, Bi-Hua
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6104686/
https://ncbi.nlm.nih.gov/pubmed/29983085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19336950.2018.1475794
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