Nanoscale Peptide Self-assemblies Boost BCG-primed Cellular Immunity Against Mycobacterium tuberculosis

Bacillus Calmette-Guerin (BCG) is the only vaccine against TB and has limited protection efficacy, which wanes past adolescence. Multifunctional CD8+ T cells (IFN-γ+/TNF-α+/IL-2+) are associated with lower reactivation risk and enhanced control of active Mtb infection. Since boosting with BCG is con...

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Publicat a:Sci Rep
Autors principals: Chesson, Charles B., Huante, Matthew, Nusbaum, Rebecca J., Walker, Aida G., Clover, Tara M., Chinnaswamy, Jagannath, Endsley, Janice J., Rudra, Jai S.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6104033/
https://ncbi.nlm.nih.gov/pubmed/30131591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-31089-y
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