Downregulating CD26/DPPIV by apigenin modulates the interplay between Akt and Snail/Slug signaling to restrain metastasis of lung cancer with multiple EGFR statuses

BACKGROUND: Metastasis rather than the primary cancer determines the survival of cancer patients. Activation of Akt plays a critical role in the epithelial-to-mesenchymal transition (EMT), the initial step in lung cancer metastasis. Apigenin (API), a flavonoid with a potent Akt-inhibitory effect, sh...

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Bibliografiske detaljer
Udgivet i:J Exp Clin Cancer Res
Main Authors: Chang, Jer-Hwa, Cheng, Chao-Wen, Yang, Yi-Chieh, Chen, Wan-Shen, Hung, Wen-Yueh, Chow, Jyh-Ming, Chen, Pai-Sheng, Hsiao, Michael, Lee, Wei-Jiunn, Chien, Ming-Hsien
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2018
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6104010/
https://ncbi.nlm.nih.gov/pubmed/30134935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-018-0869-1
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