Importance of TFEB acetylation in control of its transcriptional activity and lysosomal function in response to histone deacetylase inhibitors

TFEB (transcription factor EB) is a master regulator of lysosomal biogenesis, function and autophagy. The transcriptional activity of TFEB is mainly controlled by its phosphorylation status mediated by the MTOR (mechanistic target of rapamycin [serine/threonine kinase]) complex 1 (MTORC1). At presen...

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Dettagli Bibliografici
Pubblicato in:Autophagy
Autori principali: Zhang, Jianbin, Wang, Jigang, Zhou, Zhihong, Park, Jung-Eun, Wang, Liming, Wu, Shuai, Sun, Xin, Lu, Liqin, Wang, Tianru, Lin, Qingsong, Sze, Siu Kwan, Huang, Dongsheng, Shen, Han-Ming
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2018
Soggetti:
Research Paper - Basic Science
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6103407/
https://ncbi.nlm.nih.gov/pubmed/30059277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2018.1447290
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