A randomized placebo controlled clinical trial to evaluate the efficacy and safety of minocycline in patients with Angelman syndrome (A-MANECE study)

BACKGROUND: Minocycline is an old tetracycline antibiotic that has shown antiinflammatory and antiapoptotic properties in different neurological disease mouse models. Previous single arm study in humans demonstrated benefits in individuals with Angelman Syndrome (AS); however, its efficacy in patien...

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Detalhes bibliográficos
Publicado no:Orphanet J Rare Dis
Main Authors: Ruiz-Antoran, Belén, Sancho-López, Aranzazu, Cazorla-Calleja, Rosario, López-Pájaro, Luis Fernando, Leiva, Ágata, Iglesias-Escalera, Gema, Marín-Serrano, Maria Esperanza, Rincón-Ortega, Marta, Lara-Herguedas, Julián, Rossignoli-Palomeque, Teresa, Valiente-Rodríguez, Sara, González-Marques, Javier, Román-Riechmann, Enriqueta, Avendaño-Solá, Cristina
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6102900/
https://ncbi.nlm.nih.gov/pubmed/30126448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13023-018-0891-6
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