Promoter expression of HERV-K (HML-2) provirus-derived sequences is related to LTR sequence variation and polymorphic transcription factor binding sites

BACKGROUND: Increased transcription of the human endogenous retrovirus group HERV-K (HML-2) is often seen during disease. Although the mechanism of its tissue-specific activation is unclear, research shows that LTR CpG hypomethylation alone is not sufficient to induce its promoter activity and that...

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Vydáno v:Retrovirology
Hlavní autoři: Montesion, Meagan, Williams, Zachary H., Subramanian, Ravi P., Kuperwasser, Charlotte, Coffin, John M.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2018
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6102855/
https://ncbi.nlm.nih.gov/pubmed/30126415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12977-018-0441-2
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