Rscreenorm: normalization of CRISPR and siRNA screen data for more reproducible hit selection

BACKGROUND: Reproducibility of hits from independent CRISPR or siRNA screens is poor. This is partly due to data normalization primarily addressing technical variability within independent screens, and not the technical differences between them. RESULTS: We present “rscreenorm”, a method that standa...

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Vydáno v:BMC Bioinformatics
Hlavní autoři: Bachas, Costa, Hodzic, Jasmina, van der Mijn, Johannes C., Stoepker, Chantal, Verheul, Henk M. W., Wolthuis, Rob M. F., Felley-Bosco, Emanuela, van Wieringen, Wessel N., van Beusechem, Victor W., Brakenhoff, Ruud H., de Menezes, Renée X.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2018
Témata:
Methodology Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6102854/
https://ncbi.nlm.nih.gov/pubmed/30126372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12859-018-2306-z
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