Downregulation of microRNA-21 expression inhibits proliferation, and induces G1 arrest and apoptosis via the PTEN/AKT pathway in SKM-1 cells

Myelodysplastic syndromes (MDS) are characterized by ineffective hematopoiesis and may progress to acute myeloid leukemia (AML). MicroRNAs (miRNA/miRs) as oncogenes or tumor suppressors regulate a number of biological processes including cell proliferation, cell cycle and apoptosis in different type...

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Vydáno v:Mol Med Rep
Hlavní autoři: Li, Guang, Song, Yanping, Li, Gangcan, Ren, Jingjing, Xie, Jia, Zhang, Yunjie, Gao, Fei, Mu, Jiao, Dai, Jinqian
Médium: Artigo
Jazyk:Inglês
Vydáno: D.A. Spandidos 2018
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Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6102657/
https://ncbi.nlm.nih.gov/pubmed/30015844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/mmr.2018.9255
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