Drug Repurposing for Duchenne Muscular Dystrophy: The Monoamine Oxidase B Inhibitor Safinamide Ameliorates the Pathological Phenotype in mdx Mice and in Myogenic Cultures From DMD Patients

Oxidative stress and mitochondrial dysfunction play a crucial role in the pathophysiology of muscular dystrophies. We previously reported that the mitochondrial enzyme monoamine oxidase (MAO) is a relevant source of reactive oxygen species (ROS) not only in murine models of muscular dystrophy, in wh...

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Detalhes bibliográficos
Publicado no:Front Physiol
Main Authors: Vitiello, Libero, Marabita, Manuela, Sorato, Elisa, Nogara, Leonardo, Forestan, Giada, Mouly, Vincent, Salviati, Leonardo, Acosta, Manuel, Blaauw, Bert, Canton, Marcella
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6102489/
https://ncbi.nlm.nih.gov/pubmed/30154729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2018.01087
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