Repurposing Thioridazine (TDZ) as an anti-inflammatory agent

Nuclear factor-kB (NF-kB) is a crucial transcription factor in the signal transduction cascade of the inflammatory signaling. Activation of NF-κB depends on the phosphorylation of IκBα by IκB kinase (IKKβ) followed by subsequent ubiquitination and degradation. This leads to the nuclear translocation...

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Publicado en:Sci Rep
Autores principales: Baig, Mirza S., Roy, Anjali, Saqib, Uzma, Rajpoot, Sajjan, Srivastava, Mansi, Naim, Adnan, Liu, Dongfang, Saluja, Rohit, Faisal, Syed M., Pan, Qiuwei, Turkowski, Kati, Darwhekar, Gajanan N., Savai, Rajkumar
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6102213/
https://ncbi.nlm.nih.gov/pubmed/30127400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-30763-5
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