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Uncoupling fork speed and origin activity to identify the primary cause of replicative stress phenotypes
In growing cells, DNA replication precedes mitotic cell division to transmit genetic information to the next generation. The slowing or stalling of DNA replication forks at natural or exogenous obstacles causes “replicative stress” that promotes genomic instability and affects cellular fitness. Repl...
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| Pubblicato in: | J Biol Chem |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6102153/ https://ncbi.nlm.nih.gov/pubmed/29959228 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003740 |
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