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Parthenolide Inhibits STAT3 Signaling by Covalently Targeting Janus Kinases
Aberrant activations of the STAT3 (signal transducer and activator of transcription 3) signaling pathway are associated with cancer and inflammatory diseases. Three of the four Janus kinases, JAK1, JAK2, and Tyk2, are the major upstream kinases of STAT3 in responses to cytokine stimulations. Among t...
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| Udgivet i: | Molecules |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
MDPI
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6100543/ https://ncbi.nlm.nih.gov/pubmed/29921758 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23061478 |
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